The comparatively poor response with the combination therapy may have been due to an increase in hepatic blood flow with Iloprost and secondary accelerated clearance of rtPA. While the current study demonstrated that an increase in cardiac output per se markedly enhanced or potentiated rtPA induced pulmonary thrombolysis, a relatively low dose of rtPA was […]

In a recent study of patients with acute myocardial infarction, Rentrop et al reported that compared to treatment with streptokinase or nitroglycerine alone, there was a significant interaction between intracoronary streptokinase and nitroglycerine, resulting in a small but significant increase in left ventricular ejection fraction. While acute recanalization rates were similar between the streptokinase group […]

The marked potentiation of rtPA induced pulmonary thrombolysis by increased flow per se, is likely explained by an increase in rtPA delivery to thrombi in partially obstructed vascular units. It is also possible that the increase in cardiac output which occurred with hydralazine and with an open A-V fistula washed out, and thus, diluted clotting […]

Presumably, this explains the improvement in Pi with rtPA. On the other hand, rtPA delivery, and thus, thrombolysis, would be relatively poor in totally obstructed vascular units, those most likely responsible for the increase in IR, where resistance to blood flow is infinite. Another study of canine pulmonary embolism demonstrated that hydralazine decreased Pi. This […]

A recent study from our laboratory supports the hypothesis that changes in IR reflect changes in the number of parallel vascular units and other work demonstrates that Pi reflects the mean effective vascular outflow’ pressure. buy birth control online

In a subsequent study, employing the same model, we compared thrombolytic effects of 1 mg/kg of rtPA infused over 5 and 15 min. In this study, despite a threefold increase in rate of drug administration with the former regimen, during drug infusion, rates of pulmonary thrombolysis were similar. A third study compared effects of 1 […]

Our study investigated effects of hydralazine and an increase in CO per se on rate and extent of rtPA-induced pulmonary thrombolysis. This study was designed to test the hypothesis that pulmonary vasodilation with hydralazine would augment rtPA-induced pulmonary thrombolysis. We found that while rate and extent of pulmonary thrombolysis with rtPA were improved by pretreatment […]