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Lymphocytic and collagenous colitis: CONCLUSION

Posted in  Sunday, August 5th 2012
Topics: Collagenous colitis     Tags: Bismuth subsalicylate, Budesonide, Cholestyramine, Collagenous colitis, Lymphocytic colitis, Microscopic colitis

It is suggested that patients refractory to the above therapies should be treated with a short course of oral steroids. Most patients will have a positive response to therapy but the relapse rate is high. Pardi et al reported retrospective analyses of all patients treated at the Mayo clinic for microscopic colitis with azathioprine and […]

Lymphocytic and collagenous colitis: TREATMENT (Third-line therapy)

Posted in  Saturday, August 4th 2012
Topics: Collagenous colitis     Tags: Bismuth subsalicylate, Budesonide, Cholestyramine, Collagenous colitis, Lymphocytic colitis, Microscopic colitis

Bile acid binding agents: Use of agents that bind bile acids was reviewed in the pathogenesis section of the present paper. In short, a recent study by Ung et al found that 44% of patients with CC had abnormal bile acid absorption and that open-labelled cholestyramine (4 g per day) or colestipol (5 g per […]

Lymphocytic and collagenous colitis: TREATMENT (Second-line therapy)

Posted in  Friday, August 3rd 2012
Topics: Collagenous colitis     Tags: Bismuth subsalicylate, Budesonide, Cholestyramine, Collagenous colitis, Lymphocytic colitis, Microscopic colitis

A randomized, double-blind, placebo-controlled multicentre trial was published in October 2002 by Miehlke et al. Fifty-one patients with CC were randomly assigned to receive either budesonide (9 mg/day) or placebo for six weeks. The clinical remission in the budesonide group was 86.9% compared with 13.6% in the placebo group. Histological improvement was seen in 60.9% […]

Lymphocytic and collagenous colitis: TREATMENT (First-line therapy)

Posted in  Thursday, August 2nd 2012
Topics: Collagenous colitis     Tags: Bismuth subsalicylate, Budesonide, Cholestyramine, Collagenous colitis, Lymphocytic colitis, Microscopic colitis

Antidiarrheals: Nonspecific antidiarrheal therapy has been commonly used in the management of MC yet no published prospective or randomized studies were identified. Results of the two largest retrospective studies are included in Table 2. Due to the relative safety of these agents and the possibility of spontaneous remission, many suggest that these agents should be […]

Lymphocytic and collagenous colitis: TREATMENT (General approach)

Posted in  Wednesday, August 1st 2012
Topics: Collagenous colitis     Tags: Bismuth subsalicylate, Budesonide, Cholestyramine, Collagenous colitis, Lymphocytic colitis, Microscopic colitis

Numerous agents have been used in the treatment of MC from no therapy to high dose immune modulatory therapy. Unfortunately, most treatment approaches are based on very little significant clinical data. Thus, most physicians have adopted treating the individual patient in a stepwise approach, paying close attention to the potential side effect profile of the […]

Lymphocytic and collagenous colitis: NATURAL HISTORY

Posted in  Tuesday, July 31st 2012
Topics: Collagenous colitis     Tags: Bismuth subsalicylate, Budesonide, Cholestyramine, Collagenous colitis, Lymphocytic colitis, Microscopic colitis

The natural history of MC is not clear. The mean duration of symptoms before diagnosis in one study was two months for LC and four months for CC but these figures vary greatly. The clinical course is variable. Generally, symptoms are mild and spontaneous remissions can occur. One group reported that 84% of LC and […]

Lymphocytic and collagenous colitis: DIAGNOSIS (Part 3)

Posted in  Monday, July 30th 2012
Topics: Collagenous colitis     Tags: Bismuth subsalicylate, Budesonide, Cholestyramine, Collagenous colitis, Lymphocytic colitis, Microscopic colitis

A more recent study reported that the diagnostic yield was highest from biopsies of the transverse colon (83%) and right colon (70%) and lowest from the rectosigmoid colon (66%). In one large study, normal rectal biopsies were found in 43% of patients with CC and 8% of patients with LC. Thus, a sigmoido-scopic examination with […]

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    Adenomatous polyps, Angiogenic, Antibody-cytokine fusion proteins, antithrombotic therapy, Apoptosis, asthma, atopy, Bismuth subsalicylate, Bronchoscopy, Budesonide, cardiac output, catheterization, Cholestyramine, Collagenous colitis, Colorectal cancer, Corticosteroid, Cytokines, embolism, exercise testing, Fibrosis, Genetics, heart failure, Hemoptysis, Hepatitis C, hypoxemia, Integrin, lung volumes, Lymphocytic colitis, Lymphoma, mechanical ventilation, Microscopic colitis, neuromuscular disease, Obstructive Sleep Apnea, oral anticoagulants, oxygen therapy, Ploidy, Pneumonia, prophylaxis, prosthetic heart, pulmonary function, pulmonary thrombolysis, respiratory muscles, respiratory tract infection, supplemental oxygen, tracheostomy
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