We shall not discuss the clinical manifestations outside the respiratory tract other than to make the point that the multi-organ involvement can guide the diagnosis of the pulmonary disease. The prognosis of WG has been transformed by therapy with corticosteroids and cyclophosphamide. The case fatality rate of 7 percent reported by Fauci was especially low […]

We found no striking differences between the pulmonary manifestations of “limited’’ WG and those of “classic’’ WG (ie, with renal involvement). The concept of the limited form of WG has been proposed principally to differentiate patients with and without renal involvement, the former having the poorer prognosis. In this series, only one of the 14 […]

Lung function tests have been used in the staging and the follow up of patients with pulmonary WG, and the most common abnormality was airflow obstruction.20 Detailed lung function tests were rarely available in the present study, thus allowing no comment on this point. ventolin inhalers

Fiberoptic bronchoscopy was done in almost all patients in this series, and was abnormal in 55 percent. In most cases, endobronchial involvement consisted of nonspecific inflammatory lesions with or without stenosis. The bronchial lesions seemed to be more associated with the surrounding parenchymal involvement than isolated primary bronchial disease, and atelectasis of healthy pulmonary parenchyma […]

The most classic imaging appearance of WG is bilateral nodules, which are highly suggestive of this condition when excavated. Nevertheless, pulmonary infiltrates are common, and we could distinguish on the chest x-ray film and CT scan three broad categories of infiltrates which easily can be recognized in the data of previously published studies. Some patients […]

The aim of the present study was to precisely define the nature and frequency of the features of pulmonary WG. Cases were collected at primary specialist centers but subjected to uniform systematic analysis. This avoided the possible selection bias inherent in case collections from referral centers which may for example exclude patients who die rapidly […]

Sixteen patients (20.8 percent) in this series died because of active disease (14) or because of iatrogenic complications (two). Of the 14 patients who died with active disease, 13 had renal involvement. Diagnosis of WG had not been obtained before necropsy in four patients (5 percent) who died of active disease. Three patients died postoperatively […]