Tag: Genetics (Page 2)

Asthma

Genetics of Asthma: A Review: Asthma: Positional Cloning Approach

Positional Cloning Approach In this approach, genes are identified based on their “position” on the genetic map. This is the classic genetic approach to identifying genes. No prior knowledge of disease pathophysiology is needed. This approach consists of two broad steps. The first step is linkage analysis, in which the…

Asthma

Genetics of Asthma: A Review: Asthma: Candidate Gene Approach

Candidate Gene Approach This approach is used when some hypothesis regarding disease causation exists. A candidate gene is one whose product has functional properties that makes its involvement in disease causation likely. A gene or a group of genes that appears to be a good candidate for causing the disease…

Asthma

Genetics of Asthma: A Review: Asthma: A Complex Genetic Disease

Most genetic diseases discovered so far have been single-gene diseases, in which there is a simple relationship between a single gene abnormality and the disease phenotype (Fig 2). The relationship in single-gene diseases follows classic mendelian patterns of inheritance (ie, autosomal dominant, autosomal recessive, or sex-linked). Examples include cystic fibrosis…

Asthma

Genetics of Asthma: A Review

A sthma, a common disease affecting 3 to 4% of the US population, is a major source of disability and loss of productivity. The prevalence and severity of asthma appear to be increasing. Asthma develops because of both a genetic predisposition and the exposure to environmental factors such as allergens,…