Tag: Genetics

Asthma

Genetics of Asthma: A Review: Asthma: Conclusion

In an Australian population phenotyped for atopy and BHR, 172 affected sib-pairs were identified and screened with 269 markers spanning the entire genome. There was linkage of total serum IgE to the FceRI-P locus (chromosome llq) and to another locus on chromosome 16. BHR was linked to a locus on…

Asthma

Genetics of Asthma: A Review: Asthma: Linkage of Atopy and BHR to Chromosome 5q

Linkage of Atopy and BHR to Chromosome 5q Cytokines play a major role in the development of atopy and asthma. The genes for many of these cytokines, including interleukin-3,4,5,9,13, and gran-ulocyte-macrophage colony-stimulating factor, have been mapped to a small region on 5q31-33 known as the “cytokine-gene cluster.”66 Under the hypothesis…

Asthma

Genetics of Asthma: A Review: Asthma: Description Positional Cloning Approach

Two types of linkage analysis, parametric and nonparametric, are available. 1. Parametric Linkage Analysis: This is the classic approach and often the unqualified term “linkage analysis” is used to describe this approach. Extended pedigrees are the best substrate for this approach. A model of inheritance is proposed (hence the term…