Tag: cardiac output

Cardiac disease

Effects of Hydralazine and Increased Cardiac Output: Discussion (7)

Effects of Hydralazine and Increased Cardiac Output: Discussion (7)

The comparatively poor response with the combination therapy may have been due to an increase in hepatic blood flow with Iloprost and secondary accelerated clearance of rtPA. While the current study demonstrated that an increase in cardiac output per se markedly enhanced or potentiated rtPA induced pulmonary thrombolysis, a relatively…

Cardiac disease

Effects of Hydralazine and Increased Cardiac Output: Discussion (6)

In a recent study of patients with acute myocardial infarction, Rentrop et al reported that compared to treatment with streptokinase or nitroglycerine alone, there was a significant interaction between intracoronary streptokinase and nitroglycerine, resulting in a small but significant increase in left ventricular ejection fraction. While acute recanalization rates were…

Cardiac disease

Effects of Hydralazine and Increased Cardiac Output: Discussion (4)

Presumably, this explains the improvement in Pi with rtPA. On the other hand, rtPA delivery, and thus, thrombolysis, would be relatively poor in totally obstructed vascular units, those most likely responsible for the increase in IR, where resistance to blood flow is infinite. Another study of canine pulmonary embolism demonstrated…

Cardiac disease

Effects of Hydralazine and Increased Cardiac Output: Discussion (1)

Effects of Hydralazine and Increased Cardiac Output: Discussion (1)

Our study investigated effects of hydralazine and an increase in CO per se on rate and extent of rtPA-induced pulmonary thrombolysis. This study was designed to test the hypothesis that pulmonary vasodilation with hydralazine would augment rtPA-induced pulmonary thrombolysis. We found that while rate and extent of pulmonary thrombolysis with…