Correlations With Anesthetic Technique
The age of the patients was directly correlated with the wet weight or volume collection (r = 0.52, p = 0.005) and inversely correlated with mucus spinnability (r = 0.40, p = 0.05). As an “oral pediatric premed mixture,” which included atropine and diazepam, was given to all children younger than six years of age in this study, there was a strong correlation between the age of the patient and administration of atropine (p = 0.0001) or diazepam (p = 0.0001). For similar reasons, the age of the patient was inversely correlated with the use of narcotic induction (p = 0.001). There was a smaller volume of mucus with the preanesthetic use of atropine (p = 0.04) or diazepam (p = 0.07) and spinnability was greater when diazepam was given (45.7 mm vs 30.9 mm; p = 0.05) and was lower when a narcotic induction was used (28.6 mm vs 43.3 mm; p = 0.03).
Mucus from the Inside of the ETT Compared with That from the Outside of the ETT
In eight of the patients (six nonsmokers and two exsmokers) we were able to collect paired mucus samples from the inside of the tube exposed to anesthetic gas flow and from the outside of the ETT. In addition, we collected paired samples from nine patients who were active cigarette smokers. The paired data from the smoking patients was used only to examine the differences between inside and outside mucus and are not included for analysis in any other portion of this study. The age range of these 17 patients was 3 to 65 years (mean, 37.4 years). Duration of anesthesia was 55 to 386 minutes (mean, 141 minutes). Viscoelastic and transport properties of these paired samples are shown in Table 3. buy asthma inhalers
Although there were no significant changes in viscoelasticity between the inside and outside mucus, NFPTR was depressed an average of 29 percent in RM samples from the inside of the ETT as compared with samples taken from the outside of the ETT (p = 0.0035) and spinnability was increased an average of 41 percent for the inside mucus (p = 0.005). There was also a 39 percent decrease in percent SC for the RM samples from the inside of the ETT (p = 0.032).
Table 3—Viscoelastic and Transport Properties of Paired Mucus Samples Taken from the Inside and Outside of the ETT
|Source of Mucus|
|Property Measured||Inside ETT Mucus (N = 17)||Outside ETT Mucus (N = 17)||P Value: Paired tTest|
|Log G 1 rad/s||2.14 ±0.33||1.97 ±0.28||0.074|
|Tangent 8 1 rad/s||0.33 ±0.10||0.31 ±0.07||0.47|
|Log G 100 rad/s||2.52 ±0.34||2.35±0.28||0.10|
|Tangent 8 100 rad/s||0.71 ±0.13||0.76 ±0.14||0.18|
|Spinnability, mm||39.8 ± 11.0||23.6±9.1||0.005|
|Percent Solids (percent SC)||10.77 ±4.1||14.95±6.8||0.032|