We collected 33 samples of ETT mucus from 25 people (16 male and nine female) aged 1 to 79 years (mean, 27.8 ±22.7 years). buy asthma inhaler
Patients were excluded from the study if they had any history of pulmonary disease. None of the patients suffered from either respiratory allergies or from a respiratory tract infection in the two weeks preceding surgery. There were 20 nonsmokers and five exsmokers who had stopped tobacco consumption for at least four years before the study. Although we have demonstrated that active smokers have changes in the physical properties of their RM as compared with nonsmokers, no differences were found on any measurement of mucus properties between nonsmokers and exsmokers in this group. A variety of nonthoracic surgical procedures were performed on these patients (Table 1). Values for the physical, viscoelastic, and transport properties of this mucus are shown in Table 2 and compared with published values for mucus collected by the bronchoscopy brush technique.
The duration of anesthesia was 25 to 390 minutes (mean, 135 ±99 minutes). There was a trend toward slower normalized transport rate on the mucus-depleted frog palate (NFPTR) associated with increased anesthesia time (r = 0.354, p = 0.08). Anesthesia duration correlated with the type of surgery (p = 0.0001). Male subjects had a longer duration of anesthesia than female subjects (196 vs 92 minutes, p = 0.04) largely due to the number of short, gynecologic procedures in the female subjects. There were no sex-related differences seen in the properties of the mucus.
Table 1—Type of Surgery Performed and Anesthetic Duration
|Type of Surgery||N||Duration of Anesthesia, min|
Table 2—Physical, Viscoelastic, and Transport Properties of Mucus Collected by ETT Technique Compared With That Collected by Bronchoscopy Brush Technique
|Source of Mucus|
|Property Measured||Bronchoscopy Mucus (N = 33)||ETT Mucus (N = 33)||p Value: Unpaired tTest|
|Log G 1 rad/s||2.19 ±0.32||2.09 ±0.36||0.78|
|Tangent 8 1 rad/s||0.28 ±0.05||0.32 ±0.09||0.68|
|Log G 100 rad/s||2.58±0.33||2.48 ±0.39||0.80|
|Tangent 8 100 rad/s||0.95 ±0.26||0.76 ±0.14||0.17|
|Spinnability, mm||not measured||35.7 ±17.5|
|NFPTR||not measured||0.9 ±0.37|
|Percent Solids (percent SC)||not measured||15.96 ±7.0|