Although the observation of elevated ANP levels in patients with PPII has been made previously, the increase in ANP levels following digoxin was an unexpected finding. The increased baseline level of ANP may be related to the excess of sympathetic outflow in these patients. www.canadian-familypharmacy.com add comment ANP is secreted…
Digoxin has not been well studied in patients with isolated right ventricular dysfunction. One study in eight patients with COPD suggested that digoxin did not produce any significant changes in measured hemodynamics. However, the baseline hemodynamics in these patients, with the sole exception of pulmonary artery pressure, were normal. Another…
Effects of Digoxin on Neurohormones The mean values for plasma norepinephrine and ANP at baseline were increased compared with previously established normal values from the same laboratory (Table 2). Plasma renin activity was within the normal established range. Buy proventil add comment A significant reduction in plasma norepinephrine level (680…
Following these baseline measurements, 1 mg of digoxin was given IV in 50 mL of 5% dextrose in water over 30 min. Two hours were allowed to pass, followed by blood sampling for the neurohormonal profile. The baseline hemodynamics were reevaluated and followed by another challenge of phenylephrine and nitroprusside…
Catecholamines are quantitated in the perchloric acid extract by reversed-phased, isocratic high-performance liquid chromatography (HPLC) with coulometric electrochemical detection (ESA, Inc; Bedford, MA) on a 5-μm (Supelcosil LC-18-DB; column Supelco; Bellefonte, PA). Canadian pharmacy mall Source A specific pump is used (Spectra Physics P2000 Bioinert System; Navitech Corp; Indianapolis) and…
Hemodynamic Studies Treatment with all vasoactive medication was withheld for at least 48 h before the study. Patients underwent a diagnostic right heart catheterization after an overnight fast. Right atrial, pulmonary artery and pulmonary capillars wedge pressures, and cardiac output (in triplicate) were determined using a flow-directed thermodilution catheter advanced…
Digitalis has been used as a therapy for congestive heart failure for centuries. Although controversies have arisen about the magnitude of digoxin’s benefits, its effectiveness is well established in several controlled trials of patients with left ventricular systolic dysfunction. Conversely, digitalis is not recommended for patients with cor pulmonale. Although…