Category: Pulmonary Hypertension

Pulmonary Hypertension

The Short-term Effects of Digoxin in Patients With Right Ventricular Dysfunction From Pulmonary Hypertension: Neurohormonal Assessment

Catecholamines are quantitated in the perchloric acid extract by reversed-phased, isocratic high-performance liquid chromatography (HPLC) with coulometric electrochemical detection (ESA, Inc; Bedford, MA) on a 5-μm (Supelcosil LC-18-DB; column Supelco; Bellefonte, PA). Canadian pharmacy mall Source A specific pump is used (Spectra Physics P2000 Bioinert System; Navitech Corp; Indianapolis) and…

Pulmonary Hypertension

The Short-term Effects of Digoxin in Patients With Right Ventricular Dysfunction From Pulmonary Hypertension: Materials and Methods

Hemodynamic Studies Treatment with all vasoactive medication was withheld for at least 48 h before the study. Patients underwent a diagnostic right heart catheterization after an overnight fast. Right atrial, pulmonary artery and pulmonary capillars wedge pressures, and cardiac output (in triplicate) were determined using a flow-directed thermodilution catheter advanced…

Pulmonary Hypertension

The Short-term Effects of Digoxin in Patients With Right Ventricular Dysfunction From Pulmonary Hypertension

Digitalis has been used as a therapy for congestive heart failure for centuries. Although controversies have arisen about the magnitude of digoxin’s benefits, its effectiveness is well established in several controlled trials of patients with left ventricular systolic dysfunction. Conversely, digitalis is not recommended for patients with cor pulmonale. Although…