Category: Pregnant

Pregnant

Androgens Induce Relaxation of Contractile Activity in Pregnant Human Myometrium at Term: RESULTS

Effects of Androgens on Spontaneous Myometrial Contractility DHEA and testosterone and its 5-reduced metabolites (5a-DHT, 5p-DHT, androsterone, and androstanediol) in the concentration range of 3.0-100 |xM inhibited the spontaneous contractions of pregnant uteri at term in a concentration-dependent manner. The relaxing effect of androgens, at all concentrations tested, was significantly…

Pregnant

Androgens Induce Relaxation of Contractile Activity in Pregnant Human Myometrium at Term: MATERIALS AND METHODS

Drugs and Chemicals The following compounds were purchased from Sigma (St. Louis, MO): cholesterol (3p-hydroxy-5-cholesten), dehydroepiandrosterone (DHEA; 3p-hydroxy-5-androsten-17-one), testosterone (T; 17p-hydroxy-4-androsten-3-one), 5a-dihydrotestosterone (5a-DHT; 17p-hydroxy-5a-androstan-3-one), 5p-dihydrotestosterone (5p-DHT; 17p-hydroxy-5p-an-drostan-3-one), androsterone (3a,5a-androsterone; 3a-hydroxy-5a-andros-tan-17-one), androstanediol (3a,5a-androstanediol; 5a-androstane-3a,17p-diol), and progesterone (P; 4-pregnen-3,20-dione); the androgen receptor antagonist (flutamide), the protein synthesis inhibitor (cycloheximide), the transcription inhibitor…