Category: Lymphangiectasia

Lymphangiectasia

Intestinal lymphangiectasia in a guinea pig model (Part 4)

Our patient also failed to respond to a lipase inhibitor. Such therapy has not been previously reported in the literature but, due to her significant symptoms and requirement for massive frequent paracentesis, we felt that attempts at inhibiting lipid absorption would be beneficial. From our experience, it appears that those…

Lymphangiectasia

Intestinal lymphangiectasia in a guinea pig model (Part 3)

nitric oxide

Several studies have shown that imposed flow can inhibit the active lymph pump in both mesenteric lymphatics and in the thoracic duct. The active pump of the thoracic duct appears to be more sensitive to flow than the active pump of the mesenteric lymphatics.  Gashev et al reported that imposed…

Lymphangiectasia

Intestinal lymphangiectasia in a guinea pig model (Part 2)

This may represent one of the mechanisms of action by which octreotide induced clinical improvement in the above case reports; our studies and studies by other investigators clearly show that 5-HT can markedly reduce lymphatic pumping, leading to dilated vessels and lymph stasi. Wiest et al studied octreotide on the…

Lymphangiectasia

Intestinal lymphangiectasia in a guinea pig model (Part 1)

triglyceride

Although the above case reports indicate a benefit with the use of octreotide, the mechanism of action has not yet been identified. One speculation is that octreotide reduces intestinal blood flow, decreasing triglyceride absorption and resulting in decreased lymphatic flow and obstruction. Cohen et al found that, in patients receiving…