Category: Antithrombotic Therapy (Page 4)

Antithrombotic Therapy

Antithrombotic Therapy in Children: Therapeutic Range

Therapeutic Range: The most commonly used test for monitoring oral anticoagulant therapy is the prothrombin time (PT), reported as an INR. Unfortunately, most pediatric studies have not reported their PT results as INRs, which hinders the interpretation and generalizabil-ity of the results. Currently, therapeutic INR ranges for children are extrapolated directly…

Antithrombotic Therapy

Antithrombotic Therapy in Children: Antithrombotic Agents and the Young

Antithrombotic Agents and the Young Heparin Therapy in Pediatric Patients Mechanism of Action: Heparin’s anticoagulant activities, which are mediated by catalysis of antithrombin (AT), can be impaired in the presence of decreased plasma levels of AT. Some pediatric patients requiring heparin therapy have very low levels of AT reflecting physiologic, congenital,…

Antithrombotic Therapy

Antithrombotic Therapy in Children

Antithrombotic therapy is required for the prevention and treatment of thromboembolic complications in specific pediatric patient populations. Recommendations for antithrombotic therapy in children have been loosely extrapolated from recommendations for adults because thromboembolic events in children were rare enough to hinder testing of specific therapeutic modalities, yet common enough to…