Clinical Trials Currently Being Conducted
In general, the levels of evidence supporting guidelines for anticoagulation in children are suboptimal. The reduced incidence of thromboembolic disease in children compared to adults limits the value of single institution studies. The rapid emergence of thromboembolic complications as a major problem in tertiary pediatric health care over the last decade has led to the development of collaborative clinical trial groups. Current and future multicenter trials will provide the best evidence from which to formulate specific guidelines for the management of thromboembolic disease in children.
There are currently five ongoing multicenter, multinational, randomized, controlled trials assessing the optimal use of anticoagulants in children with or at risk for specific thromboembolic complications. The following section briefly describes these trials fully asthma medications inhalers.
REVIVE: This study (Reviparin in Venous ThromboEmbolism) is a randomized, controlled trial comparing LMWH (Reviparin) to standard heparin and warfarin for the treatment of DVT in children.
PROTEKT: This study (Prophylaxis of ThromboEmbolism in Kids Trial) is a randomized, controlled trial comparing LMWH (Reviparin) to standard of care primary prophylaxis for the prevention of DVT in children with CVLs.
FONTAN A: This is a randomized, controlled trial comparing aspirin to heparin/warfarin as primary prophylaxis against thromboembolic complications following Fontan surgery.
SLE study: This study is a randomized, placebo-controlled trial of warfarin anticoagulation (INR 2.0 to 2.5) for primary thromboembolic prophylaxis in children with systemic lupus erythematosus and antiphospholipid antibodies.
PARKAA: This study (Prophylactic Antithrombin Replacement in Kids with Acute lymphoblastic leukaemia treated with Asparaginase) is a randomized controlled trial of AT replacement as thromboembolic prophylaxis for children with acute lymphoblastic leukaemia during L-asparaginase therapy.
Antithrombotic Therapy in Children: Clinical Trials Currently Being Conducted
Clinical Trials Currently Being Conducted
- Airways Disease
- Antithrombotic Therapy
- Aortic Stenosis
- Assisted reproductive technology
- Back Pain
- Bilateral Lung
- Canadian Neighbor Pharmacy
- Cardiac disease
- cardiac pain
- Collagenous colitis
- Colorectal polyposis
- Coronary Bypass Surgery
- Crohn's disease
- Esophageal cancer
- Heart Failure
- Hepatitis C
- Hepatology and the Canadian gastroenterologist
- Human Respiratory Mucus
- Intrathoracic Goiter
- Liver cirrhosis
- Lobe Infiltrate
- Lung Disease
- Lung Injury
- Men's Health
- Myocardial Infarction
- Peripheral Vascular Disease
- Proton pump inhibitor therapy
- Pulmonary Embolism
- Pulmonary function
- Pulmonary Hypertension
- Pulmonary Wegener’s Granulomatosis
- Recurrent Pneumothorax
- Respiratory Function
- Ribonucleic Acid
- Splenic lymphoma
- Swan-Ganz Catheter
- Thrombolytic Therapy
- Transbronchial Needle Aspiration
- Trigeminal Airstream Stimulation
- Turner syndrome
- Viral hepatitis
- Viral Illnesses
- Ventolin Inhaler vs Spiriva Nebulizer: What is Better?
- Polysomnography During Sleep Apnea – Canadian Neighbor Pharmacy Explanation
- Canadian Neighbor Pharmacy: The Relation Between Surgeon Volume and Outcome Following Off-Pump vs On-Pump Coronary Artery Bypass Graft Surgery
- Canadian Neighbor Pharmacy: Results and Conclusion of Use of Calcium Channel Blockers in Hypoxic Lung Disease
- Canadian HealthCare Mall: Discussion of Endobronchial Ultrasonography Guidance for Transbronchial Needle Aspiration Using a Double-Channel Bronchoscope
TagsAdenomatous polyps, Angiogenic, Antibody-cytokine fusion proteins, antithrombotic therapy, Apoptosis, asthma, atopy, Bismuth subsalicylate, Bronchoscopy, Budesonide, cardiac output, catheterization, Cholestyramine, Collagenous colitis, Colorectal cancer, Corticosteroid, Cytokines, embolism, exercise testing, Fibrosis, Genetics, heart failure, Hemoptysis, Hepatitis C, hypoxemia, Integrin, lung volumes, Lymphocytic colitis, Lymphoma, mechanical ventilation, Microscopic colitis, neuromuscular disease, Obstructive Sleep Apnea, oral anticoagulants, oxygen therapy, Ploidy, Pneumonia, prophylaxis, prosthetic heart, pulmonary function, pulmonary thrombolysis, respiratory muscles, respiratory tract infection, supplemental oxygen, tracheostomy